COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with melphalan

Abstract Background Honey is a highly nutritional natural product that has been widely used in folk medicine for a number of therapeutic purposes.We evaluated whether Malaysian Tualang honey (AgroMas, Malaysia) was effective in reducing menopausal syndrome in ovariectomised female rats; an animal model for menopause.Methods The rats were divided in

Background: End-of-life doulas are an emerging, non-medical support and advocacy role for the dying and their caregivers.As more and more people are dying at home, research shows end-of-life doulas are increasingly in demand as non-medical advocates and companions for the dying, and their friends and families.Compassionate communities are essential

Traders do not wash hands at the time and before touched food and there are peddle food in the open side of the road and touch the food without using tools.This indicates that the risk of food sold can be contaminated with germs that cause foodborne illness.The aim of research to measure the correlation between knowledge, attitude and practice with

The article is devoted to the philosophical understanding of the problem of perception of values and antivalues.Beliefs, recognized among the people regarding the purposes to which it is important to strive for life, named values.They are the Foundation for moral principles and provide people with their human existence despite the fact that differe